Amiloride: What It Does, How to Use It, and What to Watch For

Amiloride is a potassium-sparing diuretic often used to treat high blood pressure and fluid buildup (edema). Unlike some diuretics that make you lose potassium, amiloride helps the body hold on to potassium — which can be good, but also risky if potassium gets too high. This page gives straightforward advice on why doctors prescribe it, how people usually take it, common side effects, and practical safety tips.

When and why doctors prescribe amiloride

Doctors pick amiloride for patients who need a diuretic but are at risk of losing too much potassium on other drugs like loop or thiazide diuretics. You’ll see it used for edema from heart or liver problems, and sometimes as part of combination therapy to control blood pressure. It’s often given with a thiazide to balance potassium levels while keeping the diuretic effect.

Dosing, how to take it, and practical tips

Amiloride usually comes in tablet form. Typical adult doses range from 5 mg to 10 mg once daily, though doctors sometimes adjust dose depending on response and kidney function. Take it the same time each day, with or without food. Don’t crush extended-release tablets unless the label says it’s okay. If you miss a dose, take it as soon as you remember—unless it’s near the next dose. Don’t double up.

Keep a list of all medicines and supplements you take. Avoid adding potassium supplements or salt substitutes with potassium unless your doctor approves. Some things, like ACE inhibitors, ARBs, or spironolactone, raise potassium too and can make amiloride unsafe together.

Watch for signs of high potassium: muscle weakness, tingling, or an irregular heartbeat. If any of those happen, contact your doctor or go to the ER. Your doctor will usually check blood potassium and kidney function before starting amiloride and again within a week or two, then periodically after that.

Common side effects include dizziness, headache, nausea, and increased urination. Dizziness can happen when you stand up quickly, so stand slowly and sit if you feel lightheaded. If you notice persistent stomach upset, skin rash, or any breathing problems, let your clinician know.

Amiloride isn’t recommended for people with high potassium already or for those with severe kidney problems. Pregnant or breastfeeding people should talk with their doctor about risks and benefits. Older adults may need lower doses and closer monitoring.

Store tablets at room temperature away from moisture and heat. Keep all medicines out of reach of children. If you stop amiloride, do it only under medical advice—sudden changes can affect blood pressure and fluid balance.

If you have questions about how amiloride fits into your treatment—like interactions, monitoring schedule, or what to expect—bring them up with your prescriber. A simple lab check and a short conversation can keep treatment safe and effective.